PROJECT ACTIVITIES

A 1. Management

A1.1. Management of the work, deliverables, Intellectual Property Rights (IPRs);

A1.2. Management of demonstration, exploitation;

A1.3. Scientific meetings and knowledge transfer;

A 2. Psychiatric tools adaptation to Romanian, content validity and reliability check

A2.1. Psychiatric tools Round-trip translation;

A2.2 Psychiatric tools validation;

A2.3 Reliability check;

A 3. Characterization of moderate severity negative symptoms in large adult population

A3.1. Primary clinical assessment and assembly of study cohorts;

A3.2 Negative symptoms assessment;

A3.3 General physical health status assessment;

A3.4. SMI genome-wide association study;

A3.5. Polygenic risk score assessment;

A 4. Electrophysiological/ brain imaging traits corelated with negative symptom domains

A4.1. Baseline setup for electrophysiological and brain imaging traits;

A4.2. SMI associated electrophysiological and brain imaging traits;

A4.3. Discriminant analysis of electrophysiological and brain imaging traits (Normal state vs SMI cohorts);

A 5. Neurocognitive/ social cognitive deficits associated with negative symptom domains

A5.1. Neurocognitive and social cognitive deficits quantification;

A5.2. Investigation of neurocognitive and social cognitive deficits and their association with negative symptom domains in study cohorts;

A 6. Translational study of negative symptoms in an animal model

A6.1. Pathophysiology of experiential negative symptoms in animal models;

A6.2. Discriminant analysis of reward processing steps and motivation for goal-directed behaviours;

A 7. Dissemination, Implementation and Clinical Exploitation Strategies

A7.1. Project site (within umfiasi.ro domain) & dissemination/demonstrative actions;

A7.2. Publications, data research, scientific events attendance;

A7.3. IPR transfer and implementation solutions;

A7.4. Preliminary feasibility and future clinical exploitation strategies;